Manually executing large-scale CRISPR screens is a labor-intensive process prone to human error. At the LGR, we've automated this process by leveraging advanced platforms to generate custom-made libraries at scale with reproducible standards. These libraries, combined with disease-relevant cell models in imaging-based CRISPR screens, yield data-rich phenotypic information that we pair with AI/ML-driven analysis. By providing these cutting-edge resources, we empower researchers to advance scientific discovery and improve drug development in ways that go beyond the capabilities of individual labs.

Successful functional genomics experiments depend on selecting the right system for the biology. At LGR, we design and implement custom, CRISPR-based screening platforms by optimizing cell models, libraries, and assays. These platforms enable translation of complex genetic datasets into actionable therapeutic insights.