Our Projects

One-of-a-kind environment for advancing functional genomics

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Types of Projects

We have two main groups of projects: Collaborative where UCB, UCSF and GSK investigators work together on a jointly-designed experiment and Innnovation Awards, where university investigators receive funding to pursue a project of their own design.

Innovation Awards

Each year we fund up to 10 projects via our LGR Innovation Award program, which provides pilot funds to enable cutting-edge, CRISPR-based innovation within the laboratories of UCSF and UCB faculty. Examples include, but are not limited to: single-cell sequencing applications, improved lentiviral or RNP-based delivery methods, robust genetic or chemical iPSC differential protocols, development of novel dCas9 fusion proteins for use in screens.

Collaborative Projects

An unprecedented type of joint venture where UCSF, UCB & GSK researchers work side-by-side to brainstorm, design & execute projects. From genome-wide CRISPR screens in disease-relevant cell lines to developing novel CRISPR-based toolsets, each project combines the strengths of industry & academia to deepen our understanding of genetics, discover new targets, and create next-generation technologies.

Our Projects

CRISPR has revolutionized the field of functional genomics. At the LGR, we focus on research projects with concrete outputs with the ultimate goal to deepen our understanding of genetics and discover new targets, and to create next generation technologies.

The tools that are developed in the lab will be described in published papers and will be available for use by other academic and non-profit labs.
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Types of Projects

Purple Swatch
= Innovation Awards
Black Swatch
= Collaborative Project

Lysosomal/mitochondrial interactions in LSD and SLE

UC Principal Investigator:
Roberto Zoncu
GSK Principal Investigator:
Viera Kasparcova
See Collaborating Lab

Novel Regulators of Inflammasomes in Human Myeloid Cells

UC Principal Investigator:
Russell Vance
GSK Principal Investigator:
Allison Beal
See Collaborating Lab

Development of an ALT screening platform

UC Principal Investigator:
Dirk Hockemeyer
GSK Principal Investigator:
Yanhua Rao
See Collaborating Lab

Arrayed High-Content CRISPR Screens in iPSC-Derived Neurons

UC Principal Investigator:
Martin Kampmann
GSK Principal Investigator:
Jamie Ifkovits
See Collaborating Lab

Mechanisms of sensitivity or resistance to novel and traditional DNA methylation inhibitors

AML

UC Principal Investigator:
Luke Gilbert
GSK Principal Investigator:
Michael McCabe
See Collaborating Lab
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