Get involved! Check out career opportunities
x
Laboratory for Genomics Research

Unraveling the mysteries of the human genome using CRISPR to rapidly accelerate the discovery of new medicines

State-of-the-art laboratory to advance functional genomics research and accelerate drug discovery

CRISPR Model being held up in the Lab

About Us

The goal of the Laboratory for Genomics Research (LGR) is to be a one-of-a-kind environment for collaboration between researchers at the University of California San Francisco (UCSF), the University of California Berkeley (UCB), and GlaxoSmithKline (GSK) committed to developing and deploying next-generation CRISPR technologies. The LGR represents a novel hybrid model that unites CRISPR pioneers with industry expertise under a single roof to work on projects both together and independently. Ultimately the aim is to deepen our understanding of genetics, discover new targets, and create next-generation technologies at scale that will become future standard practice for the pharmaceutical industry.
UCSF Logo
GSK Logo
UC Berkeley Logo
Injection Illustration
Goal #1
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
DNA Helix Illustration
Goal #2
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
Test Tube Illustration
Goal #3
Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.

Capabilities

Automation Suite for CRISPR Library Generation and Screening

Manually executing large-scale CRISPR screens is a laborious, time-intensive process subject to human error. The LGR is investing in automation platforms that generate custom-made libraries at scale with reproducible standards. These libraries, when combined with disease-relevant cell models in imaging-based CRISPR screens, will yield data-rich phenotypic information that can be paired with AI/ML-based analysis. Such resources will provide opportunities to advance research and improve drug discovery in ways that would be challenging in individual labs.
Library Generation Icons
Custom library generation
Tapping into our collective automation experience, the LGR is building a platform that streamlines the creation of custom arrayed and pooled genome-wide CRISPR guide libraries in both plasmid and lentiviral forms.
Screening Icon
High throughput automation
We are equipped to automate processes beginning with arrayed library cloning, then generating functionally titered arrayed lentivirus libraries, and ending with high-content screening platform to yield high-dimensional phenotypic data.
Example of Screening Report
Neurites

Customized Screens with Sophisticated Readouts

The key to a successful functional genomics experiment lies in choosing the correct screen to tackle the biological question at hand. At the LGR, we are dedicated to designing & implementing custom, CRISPR-based screening platforms. By optimizing these platforms with the most suitable cell models, libraries, and assays, we can help translate genetic datasets and generate new therapeutic targets.
Cell Plate Icon
Biologically-relevant cell-based models
To truly understand cell-type specific diseases, we have to study the disease within the appropriate context. A key focus at the LGR is to develop custom human iPSC-derived culture models that elucidate disease-specific biological mechanisms of action.
Microscope Icon
High-content imaging screens
Microscopy-based screening is a powerful tool for understanding morphological & intracellular changes. By developing high-content microscopy-based screening platforms at scale, we are enabling new tools to help us better understand disease biology & processes.
Single Cell Icon
Single-cell genetic perturbation capabilities
Single-cell transcriptome readouts can capture quantitative ‘fingerprints’ associated with genetic perturbations at the cellular level. The LGR aims to develop the best-in-class procedures for this technology, and also find ways to make it more accessible to others.

Standardizing the CRISPR toolset

While a large part of the LGR is dedicated to furthering CRISPR technology by developing sophisticated new screens coupled with automation platforms, we also recognize the importance of improving existing technologies. Although the explosion of CRISPR has produced a diverse toolset for researchers, there is still much to be done to optimize these tools for the appropriate research context. An important goal for the LGR is to create and optimize next-generation CRISPR technologies that will become future best practice.
Lab Beakers Icon
Standardization of existing protocols
The LGR is establishing broadly applicable quality control metrics to develop the best in-field practices that can be shared and disseminated.
DNA Strands Icon
Improving guide libraries
Guide libraries are a critical component of CRISPR screens. By increasing the quality of libraries, we are able to decrease experiment cost and improve screen sensitivity.
CRISPR Lab tools laid out on desk
Explore Open Positions

Join academic & industry researchers to push the boundaries of functional genomics