LASER couples damage sensing to ESCRT assembly for lysosome repairClaire S. Goul, Aakriti Jain, Samira Yitiz, Zahra E. Soltani, Serim Yang, Simon Rapp, Martina Spacci, Scot Federman, James Sacco, Huinan Li, Lauren D. Enriquez, Nalan Liv, Laralynne Przybyla & Roberto Zoncu
Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamicsParker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Dehua Zhao, Bhairavi Tolani, Steven Boggess, Angelique Di Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J. Keiser, Jamie Ifkovits, Adam Yala & Martin Kampmann
SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell typesHuinan Li, Maliha Afroze, Gunisha Arora, Scot Federman, Kaivalya Shevade, Yeqing Angela Yang, Phuong Nguyen, Rustam Esanov, Laralynne Przybyla, Adam Litterman, Shawn Shafer
Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney functionGabriel B. Loeb, Pooja Kathail, Richard W. Shuai, Ryan Chung, Reinier J. Grona, Sailaja Peddada, Volkan Sevim, Scot Federman, Karl Mader, Audrey Y. Chu, Jonathan Davitte, Juan Du, Alexander R. Gupta, Chun Jimmie Ye, Shawn Shafer, Laralynne Przybyla, Radu Rapiteanu, Nilah M. Ioannidis & Jeremy F. Reiter
Simultaneous capture of single cell RNA-seq, ATAC-seq, and CRISPR perturbation enables multiomic screens to identify gene regulatory relationshipsKaivalya Shevade, Yeqing Angela Yang, Kevin Feng, Karl Mader, Volkan Sevim, Jacob Parsons, Gunisha Arora, Hasnaa Elfawy, Rachel Mace, Scot Federman, Rustam Esanov, Shawn Shafer, Eric D. Chow, Laralynne Przybyla
Compact CRISPR genetic screens enabled by improved guide RNA library cloningSeok-Jin Heo, Lauren D. Enriquez, Scot Federman, Amy Y. Chang, Rachel Mace, Kaivalya Shevade, Phuong Nguyen, Adam J. Litterman, Shawn Shafer, Laralynne Przybyla, Eric D. Chow
2026 LGR Innovation Showcase
