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Pushpanathan Muthuirulan

LGR-GSK Investigator

Pushpanathan Muthuirulan joined the LGR as a GSK Investigator in November 2021. Prior to this role, he worked as a Research Associate at the Harvard University, where his research focused on understanding the developmental and genetic mechanisms governing biological trait formation and inheritance as well as their influence on disease risk. At the Harvard University, he used functional genomics approaches and identified two separate non-coding regulatory mutations near the Growth Differentiation factor 5 (GDF5) gene, one that can cause knee osteoarthritis in older adults and another that can cause hip dysplasia in babies. Besides these, he also worked on understanding the regulatory control of human height variation and SARS-CoV2 pathogenesis using functional genomics approaches. He received his postdoc training at the NICHD/National Institutes of Health, where his research focused on developing state-of-the-art technologies combining CRISPR-cas9 and super-resolution microscopy to map neurotransmitter receptors to neural circuits that involves visual motion information processing in Drosophila. He obtained his PhD in Microbiology from Madurai Kamaraj University, India where he discovered a novel antifungal peptide from the marine metagenome using function-based metagenomic approaches and characterized its discrete antifungal mechanisms in Candida albicans with a goal of combating opportunistic human fungal infections. Pushpanathan has broad experience and knowledge in genetics, functional genomics, molecular cell biology, developmental biology, neuroscience and microbiology. At the LGR, he is excited about leveraging his experience, skills and knowledge to contribute towards understanding the genetic architecture of complex human diseases.



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